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Congenital Afibrinogenemia


Congenital afibrinogenemia is a certain kind of rare disorder of the blood. This disease is inherited in nature. Under this disease the blood fails to clot normally. This disease is mainly seen due to defective fibrinogen, a protein necessary for blood clotting, also called coagulation factor I. The formation of the fibrinogen may either lack completely or else may lead to the formation of improper fibrinogen. This disease can be seen in both males and females of all age. The patient may be prone to severe bleeding episodes in the childhood and infancy.

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Congenital afibrinogenemia is mainly caused due to the presence of an abnormal gene in the body of the patient. This abnormal gene interferes with the proper clotting of the blood. This defective gene can pass down from any set of parents or both parents together. The fibrinogen lacks or is defective due to its inheritance in the autosomic recessive way.

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Signs & Symptoms

The patient suffering from congenital afibrinogenemia may have the following symptoms:-

  • The patient may get bruised quiet often,
  • He may also have the tendency of nose-bleeding.
  • There may be excessive bleeding after the injury or any kinds of small or major surgery.
  • The patient may also have gastrointestinal bleeding.
  • There may also be bleeding in the joints.
  • The chances of miscarriages are high.
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There is no known prevention of this disease.

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Surgery Modern Medicine

Concentrated amount of fibrinogen called cryoprecipitate may be transfused in the body of the patient through veins. Plasma may also be transfused into the body of the patient to treat the blood clotting or may be given prior to any small or major surgery. Hepatitis B vaccine must be administered to the patients of congenital afibrinogenemia to safely proceed with the transfusion process without the risk of liver damage due to infection.

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