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Primary Myelofibrosis


Primary myelofibrosis is a bone marrow disorder in which abnormalities in the blood cell production takes place along with scarring within the bone marrow. The bone marrow is a spongy and soft tissue that fills the centre part of the most of the bones. The bone marrow usually develops with the passage of time and commonly affects the people above 50 years. The alternative names of the condition are myeloid metaplasia, idiopathic myelofibrosis, myelofibrosis and agnogenic myeloid metaplasia.

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The main cause of Primary myelofibrosis is unknown. In app. 50% of the cases, mutation of the JAK2 genes can be referred as main cause

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Signs & Symptoms

The common symptoms of Primary myelofibrosis are:

  • Bone pain
  • Fatigue
  • Easy bleeding
  • Shortness of breath while performing physical work
  • Abdominal fullness related to an enlarged spleen
  • Bruising
  • Increased susceptibility to infection
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No known prevention exists for the condition.  

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Bone Marrow Transplant Modern Medicine

As such, there is no specific treatment of the condition. The treatment aims at relieving its symptoms. The treatment involves:

  • Radiation Therapy
  • Chemotherapy
  • Blood transfusion to treat anemia
  • Medicines like androgens or eythropoietin that helps in stimulating red blood cell production

If swelling causes symptoms, splenectomy is performed in which the spleen is removed. If bone marrow transplant is performed in young adults, they can lead a peaceful life

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